Dev110486 2724..2734
نویسندگان
چکیده
Neuroblast divisions in the nematode Caenorhabditis elegans often give rise to a larger neuron and a smaller cell that dies. We have previously identified genes that, when mutated, result in neuroblast divisions that generate daughter cells that are more equivalent in size. This effect correlates with the survival of daughter cells that would normally die. We now describe a role for the DEP domain-containing protein TOE-2 in promoting the apoptotic fate in the Q lineage. TOE-2 localized at the plasma membrane and accumulated in the cleavage furrow of the Q.a and Q.p neuroblasts, suggesting that TOE-2 might position the cleavage furrow asymmetrically to generate daughter cells of different sizes. This appears to be the case for Q.a divisions where loss of TOE-2 led to a more symmetric division and to survival of the smaller Q.a daughter. Localization of TOE-2 to the membrane is required for this asymmetry, but, surprisingly, the DEP domain is dispensable. By contrast, loss of TOE-2 led to loss of the apoptotic fate in the smaller Q.p daughter but did not affect the size asymmetry of the Q.p daughters. This function of TOE-2 required the DEP domain but not localization to the membrane. We propose that TOE-2 ensures an apoptotic fate for the small Q.a daughter by promoting asymmetry in the daughter cell sizes of the Q.a neuroblast division but by amechanism that is independent of cell size in theQ.p division.
منابع مشابه
GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells.
Apoptotic cell death of photoreceptors is the final event leading to blindness in the heterogeneous group of inherited retinal degenerations. GDNF (glial cell-line-derived neurotrophic factor) was found to rescue photoreceptor function and survival very effectively in an animal model of retinal degeneration (M. Frasson, S. Picaud, T. Leveillard, M. Simonutti, S. Mohand-Said, H. Dreyfus, D. Hick...
متن کاملAccess to care and the allied oral health care workforce in Kansas: perceptions of Kansas dental hygienists and scaling dental assistants.
Access to oral health care continues to be a problem in the United States. Research has called for innovative approaches to improve access to oral health care and reduce oral health care disparities. Successful alternate approaches have been reported. In 1998 the Kansas Legislature passed a proposal to enhance access to care and manpower needs by allowing dental assistants to provide supragingi...
متن کاملResearch Trends and Challenges for Network-Based ICT Systems
Welcome to this special issue of Wireless Personal Communications on Research Trends and Challenges for Network-based ICT Systems. This special issue provide an in-depth research study of the latest trends and challenges for network-based ICT systems. The convergence of information and communication technologies (ICT), have resulted into significant changes for our network infrastructures. We h...
متن کاملGranulomatous myocarditis and coelomic effusion due to Salmonella enterica arizonae in a Madagascar Dumerili's boa (Acrantophis dumerili, Jan. 1860).
A granulomatous myocarditis due to Salmonella enterica arizonae was diagnosed in an 8-year-old Madagascar Dumerili's boa (Acrantophis dumerili) based on positive coelomic effusion culture, ultrasound visualization of abnormal ventricular myocardium, necropsy and cardiac histological examination.
متن کامل